Reaktion #1543033

Reaktionsgleichung

N-(2-mercapto-ethyl)malonamic acid

ammonia

→

N-(2mercaptoethyl)malonamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas kept below or equal to 30° C
2. 2
   workup.STIRRINGStirring
3. 3
   SonstigeA slight cloudiness was removed by filtration on sintered glass
4. 4
   SonstigeThe filtrate was evaporated to dryness at reduced pressure
5. 5
   SonstigeThe solid obtained
6. 6
   Sonstigewas recrystallized from ethyl acetate
7. 7
   FiltrationAfter filtering
8. 8
   Sonstigedrying in vacuum at 50° C.

Vorschrift

31 g of methyl ester of N-(2-mercapto-ethyl)malonamic acid obtained in Example 3a) were added to 220 cm3 of aqueous 20% solution of aqueous ammonia, with stirring, while the temperature was kept below or equal to 30° C. Stirring was continued for 1 hour at ambient temperature. A slight cloudiness was removed by filtration on sintered glass. The filtrate was evaporated to dryness at reduced pressure. The solid obtained was recrystallized from ethyl acetate. After filtering and drying in vacuum at 50° C., 27 g of N-(2mercaptoethyl)malonamide were obtained in the form of a white solid with a melting point of 100° C.

Quelle