Reaktion #1536601

Reaktionsgleichung

isopropanol

4-neopentyl-3-t-butyl 1,2 dithiole perchlorate

triethylamine

→

3-isopropoxy-3-t-butyl-4-neopentyl 1,2 dithiole

Ausbeute 98.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe excess of isopropanol was removed by distillation under diminished pressure
2. 2
   workup.DISSOLUTIONThe residue was dissolved in ether
3. 3
   Filtrationthe ethereal solution was filtered
4. 4
   SonstigeThe ethereal solution was evaporated under diminished pressure

Vorschrift

To a sample of 5 grams of Example 2B, i.e., 4-neopentyl-3-t-butyl 1,2 dithiole perchlorate, in 50 grams of isopropanol was added 2.5 grams of triethylamine. The excess of isopropanol was removed by distillation under diminished pressure. The residue was dissolved in ether and the ethereal solution was filtered. The ethereal solution was evaporated under diminished pressure to yield 4.3 grams (98% of theory) of 3-isopropoxy-3-t-butyl-4-neopentyl 1,2 dithiole; n.m.r. (CCl4) in ppm, 3.97, 1H singlet (vinyl); 6.18 1H multiplet (isopropoxy); 7.17, 1H doublet (diastereotopic, J=15 cps, neopentyl; 7.88, 1H doublet (diastereotopic, J=15 cps, neopentyl); 8.62, 9H singlet (t-butyl); 8.83, 6H doublet (isopropoxy); and 8.91, 9H singlet (t-butyl).

Quelle