Reaktion #1534

Reaktionsgleichung

N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-(1-acetoxy-2-fluoroethyl)-2-thiophenesulfonamide

N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-3-(1-acetoxy-2-fluoroethyl)-2-thiophenesulfonamide

HCl

→

pure title compound

Ausbeute 92.0%

N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-3-(1-hydroxy-2-fluoroethyl)-2-thiophenesulfonamide

Ausbeute 92.0%

Lösungsmittel

sodium hydroxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with methylene chloride
2. 2
   EinengenThe extract was concentrated

Vorschrift

650 mg (0.0015 mole) of N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-(1-acetoxy-2-fluoroethyl)-2-thiophenesulfonamide synthesized in Example 4 was dissolved in 5 ml of aqueous sodium hydroxide solution and then stirred at normal temperature for one hour. The reaction mixture was adjusted to pH4 by adding 5% aqueous HCl solution and then extracted with methylene chloride. The extract was concentrated to obtain 540 mg (Yield: 92%) of the pure title compound.

Quelle