Reaktion #1533982

ord-d0cd1a3822e24aeea7f82608b29e2292

Reaktionsgleichung

C=C1CC[C@H](O)C/C1=C/C=C1\CCC[C@]2(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]12
vitamin D3
CC(=O)CC(c1ccccc1)c1c(O)c2ccccc2oc1=O
warfarin
→
C=C1CC[C@H](O)C/C1=C/C=C1\CCC[C@]2(C)[C@@H]([C@H](C)/C=C/[C@H](C)C(C)C)CC[C@@H]12
Vitamin D2

Edukte

C=C1CC[C@H](O)C/C1=C/C=C1\CCC[C@]2(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]12
vitamin D3
CC(=O)CC(c1ccccc1)c1c(O)c2ccccc2oc1=O
warfarin

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe present invention thus provides
  2. 2
    Sonstigea highly effective rodenticide preparation
  3. 3
    Sonstigeeconomically prepared in a five-step sequence which
  4. 4
    Sonstigepurification of intermediates
  5. 5
    SonstigeThe preparation of this rodenticide in about 50% yield from vitamin D
  6. 6
    SonstigeThe preparation

Vorschrift

The present invention thus provides a highly effective rodenticide preparation. The rodenticide is readily and economically prepared in a five-step sequence which does not require purification of intermediates. The preparation of this rodenticide in about 50% yield from vitamin D combined with its much higher rodenticidal activity (i.e., at least 20-30 times more potent than vitamin D3) make it a preferred agent for rodent control. The preparation should be particularly effective for the control of rats resistant to commercial rodenticides (e.g., warfarin) and is also advantageously used for the control of other rodents (e.g., mice) or other vertebrate pests (e.g., birds). The high potency of the material combined with its delayed onset of action should overcome problems of bait-avoidance or taste rejection encountered with previously known rodenticies.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04313942uspto-grants-1982_02