Reaktion #1533538

Reaktionsgleichung

3-(3-chloro-4-methoxyphenyl)-isoxazole-4-carboxylic acid

N-ethyl-N-isopropylpropan-2-amine

TBTU

3-pyridin-3-ylpyrrolidin-3-ol dihydrochloride

→

title compound

Ausbeute 50.0%

1-{[3-(3-chloro-4-methoxyphenyl)isoxazol-4-yl]carbonyl}-3-pyridin-3-ylpyrrolidin-3-ol

Ausbeute 50.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter 1 h at rt the crude product was purified by RP-HPLC
2. 2
   Extraktionextracted with ethyl acetate
3. 3
   Trocknendried (Na2SO4)
4. 4
   Sonstigeevaporated
5. 5
   Sonstigedried in vacuum

Vorschrift

A solution of 3-(3-chloro-4-methoxyphenyl)-isoxazole-4-carboxylic acid (10 mg, 0.04 mmol), N-ethyl-N-isopropylpropan-2-amine (14 μL, 0.08 mmol, 2 equ.) and TBTU (15 mg, 0.046 mmol, 1.2 equ.) in DMF (0.3 mL) was added to 3-pyridin-3-ylpyrrolidin-3-ol dihydrochloride (9 mg, 0.04 mmol). After 1 h at rt the crude product was purified by RP-HPLC. The pure fractions were basified (NaHCO3) and extracted with ethyl acetate, dried (Na2SO4), evaporated and dried in vacuum to yield the title compound (8 mg). MS (ESI, pos. ion) m/z: calcd for C20H18ClN3O4: 399.0986, found 399.0986.

Quelle