Reaktion #1533536

Reaktionsgleichung

3-(3-chloro-4-methoxyphenyl)isoxazole-4-carboxylic acid

N-ethyl-N-isopropylpropan-2-amine

TBTU

3-(2-chlorophenyl)pyrrolidin-3-ol hydrochloride

→

title compound

Ausbeute 34.6%

1-{[3-(3-chloro-4-methoxyphenyl)isoxazol-4-yl]carbonyl}-3-(2-chlorophenyl)pyrrolidin-3-ol

Ausbeute 34.6%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter 1 h at rt the crude product was purified by RP-HPLC
2. 2
   Sonstigeevaporated
3. 3
   Sonstigedried in vacuum

Vorschrift

A solution of 3-(3-chloro-4-methoxyphenyl)isoxazole-4-carboxylic acid (10 mg, 0.04 mmol), N-ethyl-N-isopropylpropan-2-amine (14 μL, 0.08 mmol, 2 equ.) and TBTU (15 mg, 0.046 mmol, 1.2 equ.) in DMF (0.3 mL) was added to 3-(2-chlorophenyl)pyrrolidin-3-ol hydrochloride (9 mg, 0.04 mmol). After 1 h at rt the crude product was purified by RP-HPLC, evaporated and dried in vacuum to yield the title compound (6 mg). MS (ESI, pos. ion) m/z: calcd for C21H18Cl2N2O4: 432.0644, found 432.0645.

Quelle