Reaktion #1533535

Reaktionsgleichung

3-(3-chloro-4-methoxyphenyl)isoxazole-4-carboxylic acid

N-ethyl-N-isopropylpropan-2-amine

TBTU

5-methyl-3-(2-methylphenyl)pyrrolidin-3-ol

→

title compound

Ausbeute 29.3%

1-{[3-(3-chloro-4-methoxyphenyl)isoxazol-4-yl]carbonyl}-5-methyl-3-(2-methylphenyl)pyrrolidin-3-ol

Ausbeute 29.3%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter 1 h at rt the crude product was purified by RP-HPLC
2. 2
   Sonstigeevaporated
3. 3
   Sonstigedried in vacuum

Vorschrift

A solution of 3-(3-chloro-4-methoxyphenyl)isoxazole-4-carboxylic acid (10 mg, 0.04 mmol), N-ethyl-N-isopropylpropan-2-amine (14 μL, 0.08 mmol, 2 equ.) and TBTU (15 mg, 0.046 mmol, 1.2 equ.) in DMF (0.3 mL) was added to 5-methyl-3-(2-methylphenyl)pyrrolidin-3-ol (8 mg, 0.04 mmol). After 1 h at rt the crude product was purified by RP-HPLC, evaporated and dried in vacuum to yield the title compound (5 mg). MS (ESI, pos. ion) m/z: calcd for C23H23ClN2O4: 426.1346, found 426.1350.

Quelle