Reaktion #1532888

Reaktionsgleichung

2-vinyl-isonicotinic acid

ozone

methyl sulfide

→

2-Formyl-isonicotinic acid

Lösungsmittel

methanol DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeozone bubbled through it until the solution
2. 2
   workup.ADDITIONadded
3. 3
   Einengenwas concentrated
4. 4
   SonstigeThe product (iic) was then purified by silica flash chromatography

Vorschrift

A solution of 2-vinyl-isonicotinic acid in methanol/DCM 1/1 was cooled to −78° C. and ozone bubbled through it until the solution becomes blue. A stream of nitrogen is then passed through to remove the ozone excess and 1.5 equivalent of methyl sulfide added. The solution was allowed to warm up to room temperature and was concentrated. The product (iic) was then purified by silica flash chromatography.

Quelle