Reaktion #1527274

Reaktionsgleichung

sodium hydroxide

ethyl 2,4,5-trifluoro-3-trifluoromethoxybenzoate

hydrochloric acid

→

2,4,5-trifluoro-3-trifluoromethoxybenzoic acid

Ausbeute 87.4%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthe reaction mixture was concentrated by evaporation under reduced pressure
2. 2
   ExtraktionThe residue was then extracted with ethyl acetate
3. 3
   WaschenThe extract was washed with water
4. 4
   Trocknendried over anhydrous sodium sulfate
5. 5
   Sonstigeevaporated to dryness under reduced pressure

Vorschrift

19.3 ml (0.0193 moles) of a 1N aqueous solution of sodium hydroxide were added t9 a solution of 5.05 g (0.0175 moles) of ethyl 2,4,5-trifluoro-3-trifluoromethoxybenzoate [(XXVIII), X=X'=F, R16 =C2H5O] [prepared as described in step (b) above] in 100 ml of ethanol, and the mixture was allowed to stand at room temperature for 2 hours. At the end of this time, 19.3 ml of 1N aqueous hydrochloric acid were added, and then the reaction mixture was concentrated by evaporation under reduced pressure. The residue was then extracted with ethyl acetate. The extract was washed with water, dried over anhydrous sodium sulfate, and evaporated to dryness under reduced pressure, to give 3.98 g of 2,4,5-trifluoro-3-trifluoromethoxybenzoic acid as a colorless powder.

Quelle