Reaktion #1524074

Reaktionsgleichung

1-benzyloxycarbonyl-2-(4-fluoro-2-methylphenyl)-4-oxo-3,4-dihydro-2H-pyridine

→

1-benzyloxycarbonyl-2-(4-fluoro-2-methylphenyl)-4-oxopiperidine

Ausbeute 86.9%

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONadded
2. 2
   SonstigeFrom the reaction mixture was removed insoluble matters
3. 3
   Filtrationby filtration
4. 4
   Sonstigethe solvent was removed by distillation under reduced pressure
5. 5
   workup.ADDITIONTo the residue was added 400 ml of ethyl acetate
6. 6
   Waschenthe mixture was washed with an aqueous sodium hydrogen carbonate solution and saturated brine
7. 7
   Trocknendried over magnesium sulfate
8. 8
   SonstigeThe solvent was removed by distillation under reduced pressure
9. 9
   Sonstigethe residue was purified by silica gel column chromatography (ethyl acetate:hexane=2:1)

Vorschrift

In 4600 ml of acetic acid was dissolved 190 g of 1-benzyloxycarbonyl-2-(4-fluoro-2-methylphenyl)-4-oxo-3,4-dihydro-2H-pyridine, and added thereto was 91 g of zinc powder and the mixture was stirred at room temperature for 24 hours. From the reaction mixture was removed insoluble matters by filtration, and the solvent was removed by distillation under reduced pressure. To the residue was added 400 ml of ethyl acetate, and the mixture was washed with an aqueous sodium hydrogen carbonate solution and saturated brine, and dried over magnesium sulfate. The solvent was removed by distillation under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate:hexane=2:1), to give 166 g of 1-benzyloxycarbonyl-2-(4-fluoro-2-methylphenyl)-4-oxopiperidine as shown in Table 125 below.

Quelle