Reaktion #1524

Reaktionsgleichung

4-hydroxymethyl-4'-decyloxybiphenyl

HBr

→

4'-bromomethyl-4-decyloxybiphenyl

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter completion of the reaction
2. 2
   Extraktionthe resultant mixture was extracted with ether
3. 3
   Waschenwashed with water, which
4. 4
   Waschenwas further washed with an aqueous solution
5. 5
   workup.ADDITIONcontaining saturated NaHCO3
6. 6
   Waschenwashed again with water
7. 7
   EinengenThe reaction product was concentrated
8. 8
   Sonstigeseparated by colomun chromatography

Vorschrift

To 0.81 g (2.51 mmol) of 4-hydroxymethyl-4'-decyloxybiphenyl was added 15 ml of an aqueous solution containing 47% HBr, and then healed at 115° C. for 3 hours. After completion of the reaction, the resultant mixture was extracted with ether and washed with water, which was further washed with an aqueous solution containing saturated NaHCO3 and washed again with water. The reaction product was concentrated and, then, separated by colomun chromatography, to thereby obtain 0.92 g of 4'-bromomethyl-4-decyloxybiphenyl.

Quelle