Reaktion #1522144

Reaktionsgleichung

Compound

{4-[5-(1-Amino-cyclohexylethynyl)-thiophen-2-yl]-pyrimidin-2-yl}-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine

hydrogen

→

(4-{5-[2-(1-Amino-cyclohexyl)-ethyl]-thiophen-2-yl}-pyrimidin-2-yl)-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas performed at room temperature
2. 2
   FiltrationAfterwards the mixture was filtered through Hyflo
3. 3
   Sonstigeevaporated
4. 4
   SonstigeThe crude was purified by chromatography on silicagel (DCM/MeOH/ammonia:85/15/1.5)

Vorschrift

Compound of Example 78 (2.5 g, 5.7 mmol) was dissolved in 200 ml MeOH and 0.8 g palladium on charcoal 10% were added. Hydrogenation was performed at room temperature and 1 bar hydrogen pressure for 8 hours. Afterwards the mixture was filtered through Hyflo and evaporated. The crude was purified by chromatography on silicagel (DCM/MeOH/ammonia:85/15/1.5). Yield: 1.6 g (64%).

Quelle