Reaktion #1519523

ord-57283b9ee7444990b5620da211b5dd22

Reaktionsgleichung

CC1CC(C(Cc2cc(F)cc(F)c2)NC(=O)C2=Cc3ccccc3Oc3ccccc32)OC1=O
Dibenzo[b,f]oxepine-10-carboxylic acid [2-(3,5-difluoro-phenyl)-1-(4-methyl-5-oxo-tetrahydrofuran-2-yl)-ethyl]-amide
CCCCN
butylamine
→
CCCCNC(=O)C(C)CC(O)C(Cc1cc(F)cc(F)c1)NC(=O)C1=Cc2ccccc2Oc2ccccc21
Dibenzo[b,f]oxepine-10-carboxylic acid [4-butylcarbamoyl-1-(3,5-difluorobenzyl)-2-hydroxy-pentyl]-amide

Edukte

CC1CC(C(Cc2cc(F)cc(F)c2)NC(=O)C2=Cc3ccccc3Oc3ccccc32)OC1=O
Dibenzo[b,f]oxepine-10-carboxylic acid [2-(3,5-difluoro-phenyl)-1-(4-methyl-5-oxo-tetrahydrofuran-2-yl)-ethyl]-amide
CCCCN
butylamine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    EinengenThe solution is concentrated in vacuo
  2. 2
    Sonstigethe residual solid recrystallized from EtOAc/hexane

Vorschrift

Dibenzo[b,f]oxepine-10-carboxylic acid [2-(3,5-difluoro-phenyl)-1-(4-methyl-5-oxo-tetrahydrofuran-2-yl)-ethyl]-amide (50 mg, 0.105 mmol) is dissolved in 2 ml butylamine and stirred for 16 h. The solution is concentrated in vacuo and the residual solid recrystallized from EtOAc/hexane. Yield 27 mg (48%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07612054B2uspto-grants-2009_11