Reaktion #1519144

Reaktionsgleichung

(1S,2R)-1-aminoindan-2-ol

triethylamine

N,N-bis(2-chloroethyl)-p-toluenesulphonamide

→

expected product

(1S,2R)-1-{4-[(4-Methylphenyl)sulphonyl]piperazin-1-yl}indan-2-ol

Lösungsmittel

dimethyl-formamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe dimethylformamide is evaporated off
2. 2
   Waschenwashed
3. 3
   Sonstigedried
4. 4
   Filtrationfiltered
5. 5
   Sonstigeevaporated
6. 6
   SonstigeThe oil obtained
7. 7
   Sonstigeis purified by flash chromatography on silica (eluant: dichloromethane/ethyl acetate 95/5)

Vorschrift

To 8 g of (1S,2R)-1-aminoindan-2-ol (53.6 mmol) dissolved in 80 ml of dimethyl-formamide there are added 15 ml of triethylamine (107.2 mmol) and 15.8 g of N,N-bis(2-chloroethyl)-p-toluenesulphonamide (53.6 mmol). The mixture is heated at 80° C. for 24 hours and then the dimethylformamide is evaporated off. The residue is taken up in dichloromethane, washed, dried, filtered and evaporated. The oil obtained is purified by flash chromatography on silica (eluant: dichloromethane/ethyl acetate 95/5) to yield the expected product in the form of a meringue.

Quelle