Reaktion #1519141

Reaktionsgleichung

compound

1a,7b-dihydro-2H-oxireno[c]chromene

tert-butyl piperidin-4-ylcarbamate

→

expected product

tert-Butyl trans-[1-(3-hydroxy-3,4-dihydro-2H-chromen-4-yl)piperidin-4-yl]-carbamate

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture is then heated
2. 2
   Temperaturat reflux for 12 hours
3. 3
   Sonstigesubsequently evaporated to dryness
4. 4
   SonstigeA yellow oil is obtained which
5. 5
   Sonstigeis purified by flash chromatography on silica (eluant: dichloromethane/ethanol 95/5)

Vorschrift

To 3 g of the compound obtained in Step B of Example 4, dissolved in 45 ml of acetonitrile, there are added 4 g of tert-butyl piperidin-4-ylcarbamate (20.2 mmol). The mixture is then heated at reflux for 12 hours and subsequently evaporated to dryness. A yellow oil is obtained which is purified by flash chromatography on silica (eluant: dichloromethane/ethanol 95/5) to yield the expected product in the form of a pale-yellow meringue.

Quelle