Reaktion #1519136

Reaktionsgleichung

ammonium hydroxide

3-nitro-2-hydroxyfluorenone

SnCl2

HCl

→

product

Ausbeute 65.0%

3-amino-2-hydroxyfluorenone

Ausbeute 65.0%

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionAfter extracting with EtOAc (3×100 ml)
2. 2
   Trocknenwere dried over magnesium sulfate
3. 3
   Sonstigeevaporated

Vorschrift

A mixture of 3-nitro-2-hydroxyfluorenone (1.6 g, 6.6 mmol) and SnCl2 (3 g, 6.6 mmol) was refluxed in 100 ml acetic acid:conc. HCl (1:1) for 1 hour. The mixture was allowed to cool to room temperature and neutralized with ammonium hydroxide. After extracting with EtOAc (3×100 ml), combined organic fractions were dried over magnesium sulfate and evaporated to leave the product as a brown solid (65%) (M+1, 212).

Quelle