Reaktion #1519135

Reaktionsgleichung

HBr

6-methoxy-7-nitro-3,4-dihydroquinazolin-4-one

→

phenol

7-nitroquinazoline-4,6-diol

Lösungsmittel

AcOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was refluxed overnight
2. 2
   SonstigeThe resulting solution was evaporated

Vorschrift

To a solution containing 20 ml of 48% aqueous HBr and 20 ml of AcOH was added 6-methoxy-7-nitro-3,4-dihydroquinazolin-4-one (1.4 g, 6.3 mmol) and the mixture was refluxed overnight. The resulting solution was evaporated to afford the crude phenol as a residue and was used without further purification (1.2 g, 5.8 mmol) (M+1, 208).

Quelle