Reaktion #1519120

Reaktionsgleichung

Z-L-Pro-OH

thionyl chloride

→

Z-L-Pro-Cl

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis heated
2. 2
   Temperaturto reflux under nitrogen for 20 minutes
3. 3
   Einengenconcentrated in vacuo
4. 4
   Einengenconcentrated

Vorschrift

A mixture of Z-L-Pro-OH E-1 (10.0 g, 40.1 mmol, 1 equiv.) and thionyl chloride (30 mL, 401.2 mmol, 10 equiv.) in DCM (200 mL) is heated to reflux under nitrogen for 20 minutes and concentrated in vacuo. The residual oil is coevaporated with toluene 3×, and concentrated to give Z-L-Pro-Cl as an opaque oil.

Quelle