Reaktion #1519118

Reaktionsgleichung

(2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid

p-TSA

→

2-(2,2-dimethyl-4-oxo-1,3-dioxolan-5-yl)hexanoic acid

Lösungsmittel

DCM

2,2-dimethoxypropane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with brine
2. 2
   Trocknendried (Na2SO4)
3. 3
   Sonstigepurified by silica gel chromatography

Vorschrift

To a solution of (2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid B-4 (300 mg, 1.58 mmol) in 2,2-dimethoxypropane (10 mL) is added p-TSA (20 mg) and the reaction is stirred at rt for 16 hours. The solution is diluted with DCM and washed with brine, dried (Na2SO4) and then purified by silica gel chromatography to afford 1.2 mmol 2-(2,2-dimethyl-4-oxo-1,3-dioxolan-5-yl)hexanoic acid B-5.

Quelle