Reaktion #1519117

Reaktionsgleichung

(2S,3R)-3-(n-butyl)-2-hydroxysuccinic dimethyl ester

NaOH

HCl

→

(2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid

Lösungsmittel

MeOH

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe MeOH is removed
2. 2
   Sonstigethe crude reaction
3. 3
   Extraktionextracted with EtOAc (3×50 mL)
4. 4
   TrocknenThe combined organic layers are dried (Na2SO4)
5. 5
   Einengenconcentrated

Vorschrift

To (2S,3R)-3-(n-butyl)-2-hydroxysuccinic dimethyl ester B-3 in MeOH (28 mL) is added a solution of NaOH (2.2 g, 55 mmol) in water (28 mL). After 24 hours, the MeOH is removed, the crude reaction is acidified with HCl (6 N, 12 mL) to pH=1, and then extracted with EtOAc (3×50 mL). The combined organic layers are dried (Na2SO4) and concentrated to give (2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid B-4.

Quelle