Reaktion #1516720

ord-f0817a01803f4defba993a9b685c8547

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCC(Oc2nc3ncc(Br)cc3s2)CC1
Compound 21B
CC(C)(C)OC(=O)N1CCC(Oc2nc3ncc(Br)cc3s2)CC1
tert-Butyl 4-(6-bromothiazolo[4,5-b]pyridin-2-yloxy)piperidine-1-carboxylate
O=C(O)C(F)(F)F
TFA
Brc1ccc2nc(OC3CCNCC3)sc2c1
Compound 1B
Brc1ccc2nc(OC3CCNCC3)sc2c1
6-Bromo-2-(piperidin-4-yloxy)benzo[d]thiazole
→
Brc1cnc2nc(OC3CCNCC3)sc2c1
Compound 21C
Brc1cnc2nc(OC3CCNCC3)sc2c1
6-Bromo-2-(piperidin-4-yloxy)thiazolo[4,5-b]pyridine

Edukte

CC(C)(C)OC(=O)N1CCC(Oc2nc3ncc(Br)cc3s2)CC1
Compound 21B
CC(C)(C)OC(=O)N1CCC(Oc2nc3ncc(Br)cc3s2)CC1
tert-Butyl 4-(6-bromothiazolo[4,5-b]pyridin-2-yloxy)piperidine-1-carboxylate
O=C(O)C(F)(F)F
TFA
Brc1ccc2nc(OC3CCNCC3)sc2c1
Compound 1B
Brc1ccc2nc(OC3CCNCC3)sc2c1
6-Bromo-2-(piperidin-4-yloxy)benzo[d]thiazole

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Compound 21C was prepared from Compound 21B and TFA in a similar manner to the procedure described for Compound 1B in Example 1. LC/MS (m/z)=314 (M+H)+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08940716B2uspto-grants-2015_01