Reaktion #1515904

Reaktionsgleichung

4-bromo-2-fluorophenyl-methanamine

methanesulfonyl chloride

→

N-(4-bromo-2-fluorobenzyl)methanesulfonamide

Ausbeute 94.2%

Lösungsmittel

dichloromethane

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe mixture was washed with water
2. 2
   TrocknenThe organic layer was dried over magnesium sulfate
3. 3
   Filtrationfiltered
4. 4
   SonstigeThe filtrate removed in vacuo
5. 5
   SonstigeThe crude was purified by column chromatography

Vorschrift

To a stirred solution of 4-bromo-2-fluorophenyl-methanamine (5.834 g, 28.592 mmol) in pyridine was added methanesulfonyl chloride (4.2 mL, 54.325 mmol) at 0° C. The reaction mixture was stirred for 1 h, then diluted with dichloromethane. The mixture was washed with water. The organic layer was dried over magnesium sulfate and filtered. The filtrate removed in vacuo. The crude was purified by column chromatography. N-(4-bromo-2-fluorobenzyl)methanesulfonamide (7.597 g) was obtained as 93% yield.

Quelle