Reaktion #1511375

ord-04afbfbe3b134a2a8d15907fea6e4f83

Reaktionsgleichung

C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)O
N-Boc-L-threonine
CC(C)(C)c1ccc(N)c(N)c1
4-tert-butyl-diaminobenzene
→
C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)c1nc2cc(C(C)(C)C)ccc2[nH]1
title compound
C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)c1nc2cc(C(C)(C)C)ccc2[nH]1
tert-Butyl [(1R,2R)-1-(5-tert-butyl-1H-benzimidazol-2-yl)-2-hydroxypropyl]carbamate

Edukte

C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)O
N-Boc-L-threonine
CC(C)(C)c1ccc(N)c(N)c1
4-tert-butyl-diaminobenzene

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared according to Method 4 Steps 1 and 2 using N-Boc-L-threonine (Preparation 52) and 4-tert-butyl-diaminobenzene.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08927587B2uspto-grants-2015_01