Reaktion #1509588

Reaktionsgleichung

Methyl 3-(tert.-butoxycarbonylamino)-5-tert-butylbenzoate

TFA

→

ethyl 3-amino-5-tert-butylbenzoate

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated in vacuum
2. 2
   workup.DISSOLUTIONThe residue was dissolved in DCM
3. 3
   Extraktionextracted with aqueous sodium bicarbonate solution
4. 4
   SonstigeThe organic layer was separated
5. 5
   Trocknendried over sodium sulphate
6. 6
   Einengenconcentrated in vacuum

Vorschrift

Methyl 3-(tert.-butoxycarbonylamino)-5-tert-butylbenzoate (0.42 g) was dissolved in DCM (5 ml). To the resulting solution, TFA (1 ml) was added, the mixture was stirred for 30 min at room temperature and then concentrated in vacuum. The residue was dissolved in DCM and extracted with aqueous sodium bicarbonate solution. The organic layer was separated, dried over sodium sulphate and concentrated in vacuum to yield ethyl 3-amino-5-tert-butylbenzoate (0.28 g), which was used for the synthesis of example 112 without further purification.

Quelle