Reaktion #1509580

Reaktionsgleichung

thiourea

Ethyl 2-bromo-4-methyl-3-oxopentanoate

→

product

Ausbeute 40.6%

Ethyl 2-amino-4-isopropylthiazole-5-carboxylate

Ausbeute 40.6%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto reflux
2. 2
   Temperaturthe reaction mixture refluxed further for 1 h
3. 3
   Einengenwas concentrated in vacuum

Vorschrift

A solution of thiourea (1.1 g) in ethanol (10 mL) was brought to reflux. Ethyl 2-bromo-4-methyl-3-oxopentanoate (3.0 g) was then added and the reaction mixture refluxed further for 1 h. The reaction was complete (by TLC) and was concentrated in vacuum. Flash chromatography (100% DCM→90:10 DCM:MeOH) afforded the product (1.1 g).

Quelle