Reaktion #1509575

Reaktionsgleichung

5-(3-Bromo-5-nitro-phenyl)-1-methyl-1H-tetrazole

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title compound

Ausbeute 15.4%

3-Bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenylamine

Ausbeute 15.4%

Lösungsmittel

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas hydrogenated on a H-cube® apparatus at 20° C.
2. 2
   SonstigeAfter reaction completion
3. 3
   Einengenthe mixture was concentrated in vacuum
4. 4
   Sonstigetriturated with MeOH
5. 5
   FiltrationThe solid was filtered
6. 6
   Sonstigefurther triturated
7. 7
   Sonstigeair-dried

Vorschrift

A solution of 5-(3-Bromo-5-nitro-phenyl)-1-methyl-1H-tetrazole (2.1 g) in EtOAc (100 ml) was hydrogenated on a H-cube® apparatus at 20° C., room pressure with a flow rate of 1 ml/min using a Raney-Ni cartridge. After reaction completion, the mixture was concentrated in vacuum and triturated with MeOH. The solid was filtered and further triturated and air-dried to give the title compound (290 mg). Rt 1.25 min (method D).

Quelle