Reaktion #1508732

Reaktionsgleichung

4-Chloro-4'-methylsulfinylmethylbenzophenone

m-chloroperbenzoic acid

→

4-chloro-4'-methylsulfonylmethylbenzophenone

Ausbeute 58.9%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter the precipitated crystals were filtered off
2. 2
   Waschenthe filtrate was successively washed with aquous sodium bicarbonate solution, aqueous 5% sodium thiosulfate solution and water
3. 3
   Trocknendried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONAfter distilling off the solvent
5. 5
   Sonstigethe crude product was purified by silica gel column chromatography (developing solvent: ethyl acetate:n-hexane=1:5)

Vorschrift

4-Chloro-4'-methylsulfinylmethylbenzophenone (2.9 g) and m-chloroperbenzoic acid (2.5 g) were dissolved in dichloromethane, and the mixture was stirred for 12 hours at 0° C. After the precipitated crystals were filtered off, the filtrate was successively washed with aquous sodium bicarbonate solution, aqueous 5% sodium thiosulfate solution and water, and dried over anhydrous magnesium sulfate. After distilling off the solvent, the crude product was purified by silica gel column chromatography (developing solvent: ethyl acetate:n-hexane=1:5) to obtain 4-chloro-4'-methylsulfonylmethylbenzophenone (1.8 g).

Quelle