Reaktion #1506233

ord-483d04d7af1945cca992174f880dbf98

Reaktionsgleichung

CC(C)N1C(=O)[C@@H](CC(=O)NCC#N)O[C@H](c2ccccc2Cl)c2cc(Cl)ccc21
Trans-7-chloro-5-(2-chlorophenyl)-3-(cyanomethylaminocarbonylmethyl)-1-isopropyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine
[N-]=[N+]=[N-].[Na+]
sodium azide
→
CC(C)N1C(=O)[C@@H](CC(=O)NCc2nnn[nH]2)O[C@H](c2ccccc2Cl)c2cc(Cl)ccc21
Trans-7-chloro-5-(2-chlorophenyl)-1-isopropyl-3-[(tetrazol-5-yl)methylaminocarbonylmethyl]-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine

Edukte

CC(C)N1C(=O)[C@@H](CC(=O)NCC#N)O[C@H](c2ccccc2Cl)c2cc(Cl)ccc21
Trans-7-chloro-5-(2-chlorophenyl)-3-(cyanomethylaminocarbonylmethyl)-1-isopropyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine
[N-]=[N+]=[N-].[Na+]
sodium azide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeto yield a crystal

Vorschrift

Trans-7-chloro-5-(2-chlorophenyl)-3-(cyanomethylaminocarbonylmethyl)-1-isopropyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine and sodium azide were subjected to the same procedure as in Example 102 to yield a crystal.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05885979uspto-grants-1999_03