Reaktion #1504231

Reaktionsgleichung

8-cyanooctanoic acid

→

9-aminononanoic acid

Ausbeute 92.5%

Lösungsmittel

isopropyl alcohol

NH3

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeare hydrogenated at 50° C.
2. 2
   FiltrationThe catalyst is filtered out
3. 3
   Einengenthe solution is concentrated
4. 4
   TemperaturCooling
5. 5
   Sonstigepurification

Vorschrift

84.5 g of 8-cyanooctanoic acid dissolved in 500 ml of isopropyl alcohol saturated with NH3 are hydrogenated at 50° C. and 80 bar for 3 hours, using 20 g of cobalt-Raney as catalyst. The catalyst is filtered out and the solution is concentrated. Cooling and purification produce 9-aminononanoic acid (80 g) in the form of a crystalline solid product with a m.p. of 190-192° C.

Quelle