Reaktion #1503379

Reaktionsgleichung

1-benzyl-4-hydroxy-4-(naphth-1-yl)piperidine

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title compound

Ausbeute 49.2%

4-hydroxy-4-(naphth-1-yl)piperidine

Ausbeute 49.2%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was then filtered through a bed of celite
2. 2
   Einengenthe filtrate concentrated under reduced pressure
3. 3
   Wascheneluting with dichloromethane containing 17% methanol
4. 4
   workup.ADDITIONFractions containing product
5. 5
   Einengenconcentrated under reduced pressure

Vorschrift

A mixture of 1.5 gm (4.7 mMol) 1-benzyl-4-hydroxy-4-(naphth-1-yl)piperidine and 0.1 gm 5% palladium on carbon in 45 mL methanol was stirred under a hydrogen atmosphere for 2 days at room temperature. The reaction mixture was then filtered through a bed of celite and the filtrate concentrated under reduced pressure. The residue was subjected to flash silica gel chromatography, eluting with dichloromethane containing 17% methanol. Fractions containing product were combined and concentrated under reduced pressure to provide 0.526 gm (49%) of the title compound as a white solid.

Quelle