Reaktion #1502858
ord-90bdff9b7c8a4264b06d3c5f7ba2c8b9
Reaktionsgleichung
N-CBZ-S-methylisothiourea
3-(3-(4-amidinopiperazin-1-ylacetamido)benzamido)propionic acid
benzyl 3-(3-(4-CBZ-amidinopiperazin-1-ylacetamido)benzamido)propionate
tert-butyl piperazin-1-ylacetate
→
tert-butyl 4-CBZ-amidinopiperazin-1-ylacetate
Edukte
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
3-(3-(4-amidinopiperazin-1-ylacetamido)benzamido)propionic acid, m.p. 270° (decomposition), from benzyl 3-(3-(4-CBZ-amidinopiperazin-1-ylacetamido)benzamido)propionate (FAB 601; obtainable by reacting tert-butyl piperazin-1-ylacetate with N-CBZ-S-methylisothiourea to give tert-butyl 4-CBZ-amidinopiperazin-1-ylacetate, cleaving the tert-butyl group with 4 N HCl in dioxane and condensing the resulting 4-CBZ-amidinopiperazin-1-ylacetic acid with benzyl 3-(3-aminobenzamido)propionate);