Reaktion #1502548

Reaktionsgleichung

3-[1-methyl-3-(5-cycloheptyl-1,3,4-thiadiazol-2-yl)ureido]propionaldehyde

hydrochloric acid

→

tetrahydro-1-(5-cycloheptyl-1,3,4-thiadiazol-2-yl)-3-methyl-6-hydroxy-2(1H)-pyrimidinone

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeequipped with a mechanical stirrer
2. 2
   Temperaturthermometer and reflux condenser
3. 3
   TemperaturThe reaction mixture is heated
4. 4
   Temperaturat reflux for a period of about 15 minutes
5. 5
   FiltrationThe reaction mixture is then filtered while hot and the filtrate
6. 6
   Temperaturis cooled
7. 7
   Sonstigeresulting in the formation of a precipitate
8. 8
   FiltrationThe precipitate is recovered by filtration
9. 9
   Sonstigeis dried
10. 10
    Sonstigeis recrystallized

Vorschrift

The dimethyl acetal of 3-[1-methyl-3-(5-cycloheptyl-1,3,4-thiadiazol-2-yl)ureido]propionaldehyde (15 grams), water (400 ml) and hydrochloric acid (4 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture is heated at reflux for a period of about 15 minutes. The reaction mixture is then filtered while hot and the filtrate is cooled resulting in the formation of a precipitate. The precipitate is recovered by filtration, is dried and is recrystallized to yield the desired product tetrahydro-1-(5-cycloheptyl-1,3,4-thiadiazol-2-yl)-3-methyl-6-hydroxy-2(1H)-pyrimidinone.

Quelle