Reaktion #1501249

Reaktionsgleichung

potassium hydroxide

product

7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidyl)-acetonyl]-4(3H)-quinazolinone hydrobromide

→

7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidyl)-acetonyl]-4(3H)-quinazolinone

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe product was washed with methanol
2. 2
   Trocknenwith water and was dried

Vorschrift

A methanolic potassium hydroxide solution (10 g of KOH/100 ml) was added to a suspension of the product of Step E in methanol and the mixture was stirred for 30 minutes at 20° C. The product was washed with methanol, then with water and was dried to obtain dextrorotary 7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidyl)-acetonyl]-4(3H)-quinazolinone melting at 205° C. and having a specific rotation of [α]D20 =+7.5° (c=1% in dimethylformamide).

Quelle