Reaktion #1491628

Reaktionsgleichung

2-phenylmorpholine

thiophen-2-yl-acetyl chloride

triethylamine

→

colorless oil

Ausbeute 88.9%

1-(2-Phenylmorpholin-4-yl)-2-(thiophen-2-yl)ethan-1-one

Ausbeute 88.9%

Lösungsmittel

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe organic solution is subsequently washed with 1 M KHSO4, 5% NaHCO3 and brine
2. 2
   TrocknenAfter drying over Na2SO4, dichloromethane
3. 3
   Sonstigeis removed in vacuo
4. 4
   Sonstigethe crude material is purified by flash chromatography (silicagel, ethyl acetate/toluene 1:3)
5. 5
   workup.ADDITIONThe fractions containing 1-(2-phenylmorpholin-4-yl)-2-(thiophen-2-yl)ethan-1-one
6. 6
   Sonstigeare collected
7. 7
   Sonstigethe solvent is removed in vacuo

Vorschrift

A solution of 2-phenylmorpholine (326 mg, 2 mmol) in dry dichloromethane (6 mL) is cooled in an ice bath, and thiophen-2-yl-acetyl chloride (401.5 mg, 2.5 mmol, 1.25 eq) and triethylamine (417 μL, 3 mmol, 1.5 eq) are added. After stirring for 6 hours at room temperature the reaction mixture is diluted with dichloromethane (10 mL). The organic solution is subsequently washed with 1 M KHSO4, 5% NaHCO3 and brine. After drying over Na2SO4, dichloromethane is removed in vacuo and the crude material is purified by flash chromatography (silicagel, ethyl acetate/toluene 1:3). The fractions containing 1-(2-phenylmorpholin-4-yl)-2-(thiophen-2-yl)ethan-1-one are collected and the solvent is removed in vacuo to give 511 mg of colorless oil.

Quelle