Reaktion #1490767

Reaktionsgleichung

(4-methoxyphenyl)methanamine

methyl 4-fluoro-2-methoxy-5-nitrobenzoate

DIEA

→

methyl 2-methoxy-4-(4-methoxybenzylamino)-5-nitrobenzoate

Ausbeute 75.0%

Lösungsmittel

water

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe solids were collected by filtration

Vorschrift

To a solution of methyl 4-fluoro-2-methoxy-5-nitrobenzoate (40 g, 174.55 mmol) in N,N-dimethylformamide (1000 mL) was added DIEA (45.2 g, 349.74 mmol). Then (4-methoxyphenyl)methanamine (31.1 g, 226.71 mmol) was added dropwise with stirring for 1 hour at 25° C. The reaction mixture was diluted with water (2 L). The solids were collected by filtration to afford methyl 2-methoxy-4-(4-methoxybenzylamino)-5-nitrobenzoate as a yellow solid (44 g, 75%).

Quelle