Reaktion #1484299

ord-187bc8e3b64342b29a9ed6fc5110722e

Reaktionsgleichung

CC(C)(C)OC(=O)NCCCC[C@@H](C(=O)O)N(Cc1ccccc1)C(=O)OCC1c2ccccc2-c2ccccc21
amino acid
CC(C)(C)OC(=O)NCCCC[C@@H](C(=O)O)N(Cc1ccccc1)C(=O)OCC1c2ccccc2-c2ccccc21
Benzyl Nα-(9-fluorenylmethoxycarbonyl)-Nε-(t-butoxycarbonyl)-L-lysine
C1CCNCC1.CN(C)C=O
piperidine DMF
→
CC(C)(C)OC(=O)NCCCC[C@H](NCc1ccccc1)C(=O)O
Benzyl Nε-(t-butoxycarbonyl)-L-lysine

Edukte

CC(C)(C)OC(=O)NCCCC[C@@H](C(=O)O)N(Cc1ccccc1)C(=O)OCC1c2ccccc2-c2ccccc21
amino acid
CC(C)(C)OC(=O)NCCCC[C@@H](C(=O)O)N(Cc1ccccc1)C(=O)OCC1c2ccccc2-c2ccccc21
Benzyl Nα-(9-fluorenylmethoxycarbonyl)-Nε-(t-butoxycarbonyl)-L-lysine
C1CCNCC1.CN(C)C=O
piperidine DMF

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Einengenthen concentrated to dryness

Vorschrift

Fmoc protected amino acid 48 (1.0 g, 1.79 mmol) was treated with a solution of piperidine/DMF (9 mL, 5% v/v) and stirred for 20 min then concentrated to dryness and used directly in the next step.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08901072B2uspto-grants-2014_12