Reaktion #1484010

Reaktionsgleichung

2-Methyl-2-thiopseudourea

ethyl ethoxymethylenecyanoacetate

K2CO3

→

4-hydroxy-2-(methylthio)pyrimidine-5-carbonitrile

Ausbeute 65.0%

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter the mixture was refluxed for 48 h
2. 2
   Filtrationfiltered
3. 3
   EinengenThe solvent was concentrated in vacuo
4. 4
   Sonstigepurified by column chromatography

Vorschrift

2-Methyl-2-thiopseudourea (5 mmol) and ethyl ethoxymethylenecyanoacetate (5 mmol) were dissolved in 20 ml EtOH. To this was added K2CO3 (10 mmol). After the mixture was refluxed for 48 h, it was cooled to room temperature and filtered. The solvent was concentrated in vacuo and purified by column chromatography to give 4-hydroxy-2-(methylthio)pyrimidine-5-carbonitrile in a yield of 65%.

Quelle