Reaktion #1483877

Reaktionsgleichung

2-(4-fluorophenyl)-7-methylsulfonyl-thiazolo[5,4-d]pyrimidin-5-amine

triethylamine

piperazine

→

title compound

Ausbeute 67.0%

2-(4-fluorophenyl)-7-(piperazin-1-yl)-thiazolo[5,4-d]pyrimidin-5-amine

Ausbeute 67.0%

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Sonstigethe volatiles were removed under reduced pressure
3. 3
   SonstigeThe crude residue was purified by flash chromatography on silica (CH2Cl2/MeOH 15:1)

Vorschrift

To a solution of 2-(4-fluorophenyl)-7-methylsulfonyl-thiazolo[5,4-d]pyrimidin-5-amine (0.40 g, 1.23 mmol) and triethylamine (0.26 ml, 1.85 mmol) in dioxane (6 ml) was added piperazine (0.16 g, 1.85 mmol). The reaction mixture was heated at 60° C. for 5 hours. After cooling, the volatiles were removed under reduced pressure. The crude residue was purified by flash chromatography on silica (CH2Cl2/MeOH 15:1), furnishing the title compound as a light yellow solid (0.27 g, 67%).

Quelle