Reaktion #1483110

Reaktionsgleichung

Octreotide pamoate

→

Pamoic Acid

Lösungsmittel

EtOAc

benzyl alcohol

—

in-water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONadded to the polymer solution
2. 2
   Sonstigeyielding a homogeneous organic phase
3. 3
   Sonstigeto provide an emulsion
4. 4
   SonstigeThe emulsion was collected directly into a 0.3% PVA solvent extraction solution (150 mL)
5. 5
   Extraktionto extract EtOAc
6. 6
   FiltrationHardened microparticles were collected by filtration
7. 7
   Waschenwashed with water, air
8. 8
   Sonstigedried
9. 9
   Sonstigestored at 4° C.

Vorschrift

Microparticle formulations (Table 5, Q-W) were prepared by an oil-in-water emulsion/solvent extraction method. PLGA polymer (MW 24,000, 180 mg) was dissolved in EtOAc (1000 μL). Octreotide pamoate (20 or 40 mg) was dissolved in benzyl alcohol (BnOH, 1000 μL) and added to the polymer solution yielding a homogeneous organic phase. The resulting organic phase was combined with a 1% PVA aqueous phase in a ratio of 1:2 to provide an emulsion. The emulsion was collected directly into a 0.3% PVA solvent extraction solution (150 mL) and stirred for four hours to extract EtOAc. Hardened microparticles were collected by filtration, washed with water, air dried and stored at 4° C.

Quelle