Reaktion #1483085

Reaktionsgleichung

pTSA

DL-alanine

dodecanol 2

→

dodecyl 2-aminopropanoate

Ausbeute 110.8%

Dodecyl 2-aminopropanoate

Ausbeute 110.8%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONAfter addition
2. 2
   Temperaturthe temperature of the reaction mixture was slowly raised
3. 3
   Temperaturto reflux temperature
4. 4
   Sonstigethe water was separated azeotropically
5. 5
   EinengenThe reaction mixture was concentrated under vacuum
6. 6
   Waschenwashed with aqueous 5% Na2CO3 (3×50 mL)
7. 7
   TrocknenThe organic layer was dried over Na2SO4
8. 8
   Einengenconcentrated under vacuum

Vorschrift

To a stirred solution of DL-alanine 1 (5 g, 56.1 mmol) in toluene (100 mL) was added dodecanol 2 (9.42 g, 50.5 mmol) in one lot, followed by pTSA (11.75 g, 61.7 mmol). After addition, the temperature of the reaction mixture was slowly raised to reflux temperature, the water was separated azeotropically, and the reaction mixture was monitored by TLC. The reaction mixture was concentrated under vacuum, the obtained residue was taken in ethyl acetate (200 mL) and washed with aqueous 5% Na2CO3 (3×50 mL) followed by brine solution. The organic layer was dried over Na2SO4 and concentrated under vacuum to afford crude dodecyl 2-aminopropanoate 3 (14.4 g, yield: 100%) as a liquid.

Quelle