Reaktion #1483025

Reaktionsgleichung

dichlorosalicylic acid

2-acetoxyacetoxy-3,5-dichlorobenzoic acid

2-acetoxyacetoxy-3,5-dichlorobenzoic acid chloride

2-acetoxy-acetoxy-3,5-dichlorobenzoic acid

N-(2-hydroxy-3,5-dichlorobenzoyl)-L-phenylalanine

→

L-phenylalanine ethyl ester

N-(2-acetoxy-3,5-dichlorobenzoyl)-L-phenylalanine

2-acetoxyacetoxy-3,5-dichlorobenzoic acid chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe invention also provides a method

Vorschrift

The invention also provides a method for synthesizing N-(2-hydroxy-3,5-dichlorobenzoyl)-L-phenylalanine, comprising: converting 3-5 dichlorosalicylic acid into 2-acetoxy-acetoxy-3,5-dichlorobenzoic acid; converting 2-acetoxyacetoxy-3,5-dichlorobenzoic acid into 2-acetoxyacetoxy-3,5-dichlorobenzoic acid chloride; reacting 2-acetoxyacetoxy-3,5-dichlorobenzoic acid chloride with L-phenylalanine ethyl ester to form N-(2-acetoxy-3,5-dichlorobenzoyl)-L-phenylalanine; and converting N-(2-acetoxy-3,5-dichlorobenzoyl)-L-phenylalanine into N-(2-hydroxy-3,5-dichlorobenzoyl)-L-phenylalanine. In some embodiments, the converting comprises hydrolyzing of ester functions in N-(2-acetoxy-3,5-dichlorobenzoyl)-L-phenylalanine.

Quelle