Reaktion #1482966

Reaktionsgleichung

5-aminomethyl-1,3,4-thiadiazole-2-thiol hydrochloride

t-butoxycarbonyl azide

→

5-t-butoxycarbonylaminomethyl-1,3,4-thiadiazole-2-thiol

Ausbeute 65.2%

Lösungsmittel

water

dioxane

triethylamine

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONwas distilled off under reduced pressure
2. 2
   Extraktionextracted twice with ethyl acetate
3. 3
   WaschenThe extract was washed with a saturated aqueous solution of sodium chloride
4. 4
   Trocknendried over magnesium sulfate
5. 5
   Sonstigeevaporated to dryness

Vorschrift

To a mixture of 5-aminomethyl-1,3,4-thiadiazole-2-thiol hydrochloride (5.5 g) in water (50 ml), dioxane (50 ml) and triethylamine (15 ml) was added t-butoxycarbonyl azide (5.6 g) and the mixture was stirred for 24 hours at 40° to 45° C. After the reaction was over, the dioxane was distilled off under reduced pressure. The residue was adjusted to pH2 with 10% hydrochloric acid and extracted twice with ethyl acetate. The extract was washed with a saturated aqueous solution of sodium chloride and then dried over magnesium sulfate and then evaporated to dryness to give 5-t-butoxycarbonylaminomethyl-1,3,4-thiadiazole-2-thiol (4.83 g). m.p. 144° to 146° C.

Quelle