Reaktion #1481719

ord-1eee7eb1252b44bba5e80232d624fa2e

Reaktionsgleichung

COC(=O)c1ccc(C#C[Se]c2ccc3c(c2)C(C)(C)CC=C3c2ccc(C)cc2)cc1F
methyl 4-(8,8-dimethyl-5-p-tolyl-7,8-dihydro-2-naphthylselanylethynyl)-2-fluorobenzoate
[Na+].[OH-]
sodium hydroxide
→
Cc1ccc(C2=CCC(C)(C)c3cc([Se]C#Cc4ccc(C(=O)O)c(F)c4)ccc32)cc1
4-(8,8-Dimethyl-5-p-tolyl-7,8-dihydro-2-naphthylselanylethynyl)-2-fluorobenzoic acid

Edukte

COC(=O)c1ccc(C#C[Se]c2ccc3c(c2)C(C)(C)CC=C3c2ccc(C)cc2)cc1F
methyl 4-(8,8-dimethyl-5-p-tolyl-7,8-dihydro-2-naphthylselanylethynyl)-2-fluorobenzoate
[Na+].[OH-]
sodium hydroxide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigea yellow solid is obtained (0.77 g; yield=63%; m.p.=145° C.)

Vorschrift

In a manner similar to that of Example 7d, by reacting 1.28 g (2.5 mmol) of methyl 4-(8,8-dimethyl-5-p-tolyl-7,8-dihydro-2-naphthylselanylethynyl)-2-fluorobenzoate with 0.51 g (13 mmol) of sodium hydroxide, a yellow solid is obtained (0.77 g; yield=63%; m.p.=145° C.).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07348449B2uspto-grants-2008_03