Reaktion #1481712

ord-f7a67c19fa1b4bf98e2efcc5f85ba482

Reaktionsgleichung

COC(=O)C=C(C)C#C[Se]c1ccc2c(c1)C(C)(C)CC=C2c1ccc(C)cc1
methyl 5-(8,8-dimethyl-5-p-tolyl-7,8-dihydro-2-naphthylselanyl)-3-methylpent-2-en4-ynoate
O.[Li+].[OH-]
lithium hydroxide monohydrate
→
CC(C#C[Se]c1ccc2c(c1)C(C)(C)CC=C2c1ccc(C)cc1)=CC(=O)O
5-(8,8-Dimethyl-5-p-tolyl-7,8-dihydro-2-naphthylselanyl)-3-methylpent-2-en-4-ynoic acid

Edukte

COC(=O)C=C(C)C#C[Se]c1ccc2c(c1)C(C)(C)CC=C2c1ccc(C)cc1
methyl 5-(8,8-dimethyl-5-p-tolyl-7,8-dihydro-2-naphthylselanyl)-3-methylpent-2-en4-ynoate
O.[Li+].[OH-]
lithium hydroxide monohydrate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigea pale yellow solid is obtained (0.05 g; yield=23%; m.p.=166° C.)

Vorschrift

In a manner similar to that of Example 1g, by reacting 0.23 g (0.5 mmol) of methyl 5-(8,8-dimethyl-5-p-tolyl-7,8-dihydro-2-naphthylselanyl)-3-methylpent-2-en4-ynoate with 0.23 g (5.5 mmol) of lithium hydroxide monohydrate, a pale yellow solid is obtained (0.05 g; yield=23%; m.p.=166° C.).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07348449B2uspto-grants-2008_03