Reaktion #1475478

Reaktionsgleichung

chloromethyl methyl sulfide

2-acetylamino-4-hydroxy-1-indanone

sodium hydride

Water

→

desired product

2-acetylamino-4-(methylthiomethoxy)-1-indanone

Lösungsmittel

HMPA

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture is stirred overnight
2. 2
   Extraktionthe mixture is extracted with ethyl acetate which
3. 3
   Waschenis back-washed with water
4. 4
   SonstigeAfter drying
5. 5
   Einengen(Na2SO4) and concentration

Vorschrift

To 2-acetylamino-4-hydroxy-1-indanone 10.25 g (0.05 m) in 50 ml of dry HMPA under N2 is added 2.6 g (0.055 m) of a 50% oil dispersion of sodium hydride in portions. After stirring at room temperature for 1/2 hr, 5.3 g (0.055 m) of chloromethyl methyl sulfide is added, and the mixture is stirred overnight. Water is added and the mixture is extracted with ethyl acetate which is back-washed with water. After drying (Na2SO4) and concentration, the desired product is obtained.

Quelle