Reaktion #1473392

Reaktionsgleichung

2-amino-6-fluoronicotinamide

triethyl orthoformate

→

7-fluoropyrido[2,3-d]pyrimid-4(3H)-one

Ausbeute 96.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis heated
2. 2
   Temperaturat reflux for 8 h
3. 3
   Filtrationis filtered off
4. 4
   Waschenwashed well with petroleum ether

Vorschrift

A suspension of 2-amino-6-fluoronicotinamide (0.74 g, 4.77 mmol) in triethyl orthoformate (25 mL) is heated at reflux for 8 h. After cooling to room temperature the precipitate is filtered off and washed well with petroleum ether to give 7-fluoropyrido[2,3-d]pyrimid-4(3H)-one (0.76 g, 96%), 1H NMR (DMSO) δ 12.75 (1H, brs), 8.66 (1H, dd, J=10.4, 8.4 Hz), 8.38 (1H, s), 7.33 (1H, dd, J=8.4, 2.6 Hz).

Quelle