Reaktion #1472226

Reaktionsgleichung

8-methylquinoline-5-carboxylic acid

hydrogen

→

8-Methyl-1,2,3,4-tetrahydroquinoline-5-carboxylic acid

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas reduced in an autoclave at 50° C.
2. 2
   FiltrationThe reaction mixture was then filtered
3. 3
   Waschenthe filter cake was washed with ethanol
4. 4
   Einengenthe combined organic filtrates were concentrated

Vorschrift

0.1 mol of 8-methylquinoline-5-carboxylic acid was suspended in 1.5 l of ethanol and admixed with 10.0 g of palladium on activated carbon (5%). Over a period of 48 hours, the mixture was reduced in an autoclave at 50° C. using hydrogen (1 bar) (HPLC control). The reaction mixture was then filtered, the filter cake was washed with ethanol and the combined organic filtrates were concentrated.

Quelle