Reaktion #1472085

Reaktionsgleichung

2-chloro-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline

morpholine

isopropyl alcohol

→

title compound

Ausbeute 79.8%

2-Morpholino-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline

Ausbeute 79.8%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturunder reflux for 3 hours
3. 3
   Temperaturunder heating
4. 4
   SonstigeThe precipitate thus formed
5. 5
   Filtrationwas recovered by filtration
6. 6
   Waschenwashed with 30 ml of water and 30 ml of ethyl acetate

Vorschrift

A mixture comprising 338 mg of 2-chloro-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline, 435 mg of morpholine and 20 ml of isopropyl alcohol was heated under reflux for 3 hours, followed by the addition of 30 ml of water under heating. The precipitate thus formed was recovered by filtration and washed with 30 ml of water and 30 ml of ethyl acetate. Thus, 310 mg of the title compound was obtained.

Quelle