Reaktion #1471979

Reaktionsgleichung

1-diphenylmethyl-3-morpholinoazetidine

hydrochloric acid

→

title compound

3-morpholinoazetidine dihydrochloride

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe catalyst was then removed by filtration
2. 2
   Sonstigethe filtrate evaporated to dryness
3. 3
   workup.ADDITIONAddition of dichloromethane (100 ml) to the residue and trituration
4. 4
   Sonstigegave a solid which
5. 5
   Sonstigewas recrystallised from methanol

Vorschrift

A mixture of 1-diphenylmethyl-3-morpholinoazetidine (prepared in an analogous manner to the compound of preparation 22 above) (18.6 g), palladium hydroxide (2 g), ethanol (200 ml) and 1N aqueous hydrochloric acid solution (52 ml) was stirred under an atmosphere of hydrogen at 345 kPa (50 p.s.i.) for 3 days. The catalyst was then removed by filtration and the filtrate evaporated to dryness. Addition of dichloromethane (100 ml) to the residue and trituration gave a solid which was recrystallised from methanol to give the title compound (10.2 g).

Quelle