Reaktion #1470515

Reaktionsgleichung

4-methyl-1-(2-methyl-1H-indol-4-yl)piperazine

oxychloride

N,N-dimethylformamide

N,N-dimethylformamide

sodium hydroxide

→

title compound

Ausbeute 22.0%

1-(3-Formyl-2-methyl-1H-indol-4-yl)-4-methylpiperazine

Ausbeute 22.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe resulting reaction solution
2. 2
   workup.STIRRINGthe resulting solution was stirred at room temperature under nitrogen overnight
3. 3
   SonstigeThe reaction solution was then evaporated under reduced pressure
4. 4
   Sonstigethe residue was chromatographed
5. 5
   Waschensilica gel (approximately 50 g) and elution with methylene chloride/methanol/ammonium hydroxide [10:1:0.1]

Vorschrift

To a stirred solution of 4-methyl-1-(2-methyl-1H-indol-4-yl)piperazine (0.247 g, 1.08 mmol) in anhydrous N,N-dimethylformamide (1 mL) at 0° C. was added dropwise a solution of phorsphorus oxychloride (0.16 g, 1.04 mmol) in anhydrous N,N-dimethylformamide (1 mL). The resulting reaction solution was stirred at room temperature under nitrogen for 2 hours. An aqueous solution of sodium hydroxide (10% by weight, 3 mL) was then added, and the resulting solution was stirred at room temperature under nitrogen overnight. The reaction solution was then evaporated under reduced pressure, and the residue was chromatographed using silica gel (approximately 50 g) and elution with methylene chloride/methanol/ammonium hydroxide [10:1:0.1] to afford the title compound (0.060 g, 0.23 mmol, 22%) as an off-white foam: 1H NMR (DMSO-d6) δ12.14 (br s, NH), 10.46 (s, 1H), 7.14-7.08 (m, 2H), 6.88 (dd, J=1.4 and 7.1 Hz, 1H), 3.11 (br m, 8H), 2.66 (s, 3H); FAB LRMS (m/z, relative intensity) 259 (16), 258 (MH+, 100).

Quelle